Consolidating new memories requires the amygdala and
The hippocampus is involved in the recognition of place and the consolidation of contextual memories, and is part of a region called the medial temporal lobe (MTL), that also includes the perirhinal, parahippocampal,and entorhinal cortices.Lesions in the medial temporal lobe typically produce amnesia characterized by the disproportionate loss of recently acquired memories."Consolidation" is a term that is bandied about a lot in recent memory research. Initially, information is thought to be encoded as patterns of neural activity — cells "talking" to each other.
C/EBPβ is an evolutionarily conserved genetic marker that has a selective role in the consolidation of new but not reactivated memories in the hippocampus.When recalled, memories re-enter a new phase of vulnerability and seem to require a reconsolidation process in order to be maintained.Here we show that consolidation but not reconsolidation of inhibitory avoidance memory requires the expression of the transcription factor CCAAT enhancer binding protein β (C/EBPβ) in the hippocampus.This raises the question: does reconsolidation involve the previously stable representation, or the establishment of a new representation, that coexists with the old?Whether reconsolidation is the creating of a new representation, or the modifying of an old, is this something other than the reconstruction of memories as they are retrieved?